abstract：BACKGROUND:Recently, there have been increasingly frequent reports on the occurrence of macrophage activation syndrome (MAS) in patients with inflammatory bowel disease (IBD). Clinically, MAS is characterized mainly by fever, hepatosplenomegaly, cytopenia, and elevated circulating ferritin and CD25. Mortality, even if ...

journal_title：Alimentary pharmacology & therapeutics

authors： Fries W,Cottone M,Cascio A

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), is a systemic disorder that predominantly affects the bowels but is also associated with venous thromboembolism (VTE). AIM:To provide a quantitative assessment of the association of IBD with venous thromboembo...

journal_title：Alimentary pharmacology & therapeutics

authors： Yuhara H,Steinmaus C,Corley D,Koike J,Igarashi M,Suzuki T,Mine T

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Current guidelines recommend the cessation of clopidogrel therapy 5 days and 7-10 days prior to colonoscopic polypectomy. Recent studies have advocated for continued clopidogrel as post-polypectomy bleeding (PPB) rates have been similar to those in the general population not on antithrombotic therapy. AIM:T...

journal_title：Alimentary pharmacology & therapeutics

authors： Gandhi S,Narula N,Mosleh W,Marshall JK,Farkouh M

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Recently, the therapeutic landscape with regard to anti-HCV therapy has changed dramatically. The new directly acting anti-virals (DAAs) have demonstrated improved sustained virological response (SVR) compared with pegylated-interferon and ribavirin. AIM:To examine and present the latest data with regard to...

journal_title：Alimentary pharmacology & therapeutics

authors： Joshi D,Carey I,Agarwal K

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Microscopic colitis (MC) is a common chronic diarrhoeal disease, and remission can be induced with budesonide. However, diarrhoea relapses frequently when budesonide is tapered and a few patients become budesonide intolerant. AIM:To examine retrospectively the effect of azathioprine (AZA) and mercaptopurine...

journal_title：Alimentary pharmacology & therapeutics

authors： Münch A,Fernandez-Banares F,Munck LK

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Gastrointestinal (GI) symptoms are common in soldiers in combat or high-pressure operational situations and often lead to compromised performance. Underlying mechanisms are unclear, but neuroendocrine dysregulation, immune activation and increased intestinal permeability may be involved in stress-related GI ...

journal_title：Alimentary pharmacology & therapeutics

authors： Li X,Kan EM,Lu J,Cao Y,Wong RK,Keshavarzian A,Wilder-Smith CH

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:While current medications used to treat patients with chronic hepatitis C virus (HCV) effectively produce sustained viral response (SVR), postponement of therapy is often times attributed to patient perceptions of unfavourable outcomes. However, an instrument to assess patient perceptions of therapy (i.e. tr...

journal_title：Alimentary pharmacology & therapeutics

authors： Szeinbach SL,Baran RW,Dietz B,Gazzouola Rocca L,Littlefield D,Yawn BP

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Psychiatric co-morbidity, in particular major depression and anxiety, is common in patients with Crohn's disease (CD) and ulcerative colitis (UC). Prior studies examining this may be confounded by the co-existence of functional bowel symptoms. Limited data exist examining an association between depression or...

journal_title：Alimentary pharmacology & therapeutics

authors： Ananthakrishnan AN,Gainer VS,Perez RG,Cai T,Cheng SC,Savova G,Chen P,Szolovits P,Xia Z,De Jager PL,Shaw SY,Churchill S,Karlson EW,Kohane I,Perlis RH,Plenge RM,Murphy SN,Liao KP

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Chronic hepatitis C (HCV) treatment with pegylated-interferon (PEG-IFN)/ribavirin (RBV) is often limited by preexisting medical, psychiatric and psychosocial contraindications. However, limited data exist in general patient populations. AIM:To evaluate the percentage of HCV-infected patients in the general ...

journal_title：Alimentary pharmacology & therapeutics

authors： Talal AH,LaFleur J,Hoop R,Pandya P,Martin P,Jacobson I,Han J,Korner EJ

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Liver transplantation is potentially a life-saving therapeutic intervention for patients with portopulmonary hypertension and hepatopulmonary syndrome. However, due to limited data, listing criteria for patients with these conditions have not been clearly established. Indeed, this has led some to speculate t...

journal_title：Alimentary pharmacology & therapeutics

authors： Houlihan DD,Holt A,Elliot C,Ferguson JW

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Deregulation of mammalian target of rapamycin (mTOR) signalling is common in human hepatocellular carcinoma (HCC). AIM:To determine the maximum tolerated dose (MTD) of the oral mTOR inhibitor everolimus in advanced HCC patients. METHODS:Patients with locally advanced or metastatic HCC (Child-Pugh class A o...

journal_title：Alimentary pharmacology & therapeutics

authors： Shiah HS,Chen CY,Dai CY,Hsiao CF,Lin YJ,Su WC,Chang JY,Whang-Peng J,Lin PW,Huang JD,Chen LT

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Sorafenib is currently the only approved systemic therapy shown to have efficacy in the treatment of advanced hepatocellular carcinoma (HCC). Recent studies suggest that hepatitis C (HCV)-related HCC patients derive more clinical benefit from sorafenib than other subgroups, but the mechanism for this effect ...

journal_title：Alimentary pharmacology & therapeutics

authors： Cabrera R,Limaye AR,Horne P,Mills R,Soldevila-Pico C,Clark V,Morelli G,Firpi R,Nelson DR

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Clostridium difficile can cause severe antibiotic-associated colitis. Conventional treatments with metronidazole and vancomycin improve symptoms, but after discontinuation of treatment, C. difficile infection (CDI) recurs in a number of patients. Rifaximin is a rifamycin-based non-systemic antibiotic that ha...

journal_title：Alimentary pharmacology & therapeutics

authors： Mattila E,Arkkila P,Mattila PS,Tarkka E,Tissari P,Anttila VJ

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Limited data are available on the efficacy and safety of antiviral therapy in geriatric patients with chronic hepatitis C virus (HCV) infection. AIM:To evaluate the efficacy and safety of pegylated interferon (pegIFN) plus ribavirin (RBV) therapy in geriatric HCV-infected patients. METHODS:Ninety-one geria...

journal_title：Alimentary pharmacology & therapeutics

authors： Hu CC,Lin CL,Kuo YL,Chien CH,Chen SW,Yen CL,Lin CY,Chien RN

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Steroid-refractory ulcerative colitis (UC) remains a challenging condition warranting surgery upon failure of pharmacological treatment. Calcineurin inhibitors or infliximab are alternatives in this situation. Data on the efficacy and safety of tacrolimus in this setting are limited. AIM:To study the short-...

journal_title：Alimentary pharmacology & therapeutics

authors： Schmidt KJ,Herrlinger KR,Emmrich J,Barthel D,Koc H,Lehnert H,Stange EF,Fellermann K,Büning J

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:There is clear benefit from combination therapy with infliximab and immunosuppressive drugs (IS), but few data are available for adalimumab (ADA). AIM:To assess the efficacy of ADA monotherapy and ADA+IS for induction and maintenance therapy in Crohn's disease. METHODS:Retrospective study of patients with ...

journal_title：Alimentary pharmacology & therapeutics

authors： Reenaers C,Louis E,Belaiche J,Seidel L,Keshav S,Travis S

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Incomplete resorption of fructose results in increased colonic hydrogen production and is a frequent cause of abdominal symptoms. The only treatment available is diet. AIM:To study whether orally administered xylose isomerase (XI), an enzyme that catalyses the reversible isomerisation of glucose and fructos...

journal_title：Alimentary pharmacology & therapeutics

authors： Komericki P,Akkilic-Materna M,Strimitzer T,Weyermair K,Hammer HF,Aberer W

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Idiopathic noncirrhotic portal hypertension (INCPH) has been reported increasingly in patients with HIV infection. AIM:To evaluate the number of nationwide diagnosed HIV-associated INCPH cases and to assess its clinical features, risk factors and outcome. METHODS:All HIV centres in the Netherlands were con...

journal_title：Alimentary pharmacology & therapeutics

authors： Schouten JN,Van der Ende ME,Koëter T,Rossing HH,Komuta M,Verheij J,van der Valk M,Hansen BE,Janssen HL

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Eosinophilic oesophagitis (EoE) has evolved from a supposedly rare entity to one whose incidence rates are approaching that of inflammatory bowel disease. The factors responsible for this apparent increase in the incidence remain obscure. AIM:To assess various endoscopist and pathologist factors that might ...

journal_title：Alimentary pharmacology & therapeutics

authors： Syed AA,Andrews CN,Shaffer E,Urbanski SJ,Beck P,Storr M

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:A variety of tests have been proposed for colorectal cancer (CRC), giving rise to uncertainty regarding the optimal approach. The efficacy and effectiveness of different tests are related to both screened participation and the detection rate. AIM:To perform a meta-analysis on adherence and detection rates o...

journal_title：Alimentary pharmacology & therapeutics

authors： Hassan C,Giorgi Rossi P,Camilloni L,Rex DK,Jimenez-Cendales B,Ferroni E,Borgia P,Zullo A,Guasticchi G,HTA Group.

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Symptoms of lactose intolerance are often attributed to lactose malabsorption but, as this relationship has not been demonstrated when a small dose of lactose similar to that contained in one cup of milk is ingested by intolerant patients, psychological factors may play a role in altered symptom perception. ...

journal_title：Alimentary pharmacology & therapeutics

authors： Tomba C,Baldassarri A,Coletta M,Cesana BM,Basilisco G

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Proton pump inhibitors (PPIs) are potent inhibitors of gastric acid secretion and give hypergastrinemia secondary to gastric hypoacidity. PPI treatment therefore induces enterochromaffin-like (ECL) cell hyperplasia. Long-term hypergastrinemia in rodents and man also leads to ECL cell neoplasia. Whether long-...

journal_title：Alimentary pharmacology & therapeutics

authors： Jianu CS,Fossmark R,Viset T,Qvigstad G,Sørdal O,Mårvik R,Waldum HL

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Gastroprotective strategies are recommended for nonsteroidal anti-inflammatory drug (NSAID) users at risk of upper gastrointestinal (UGI) complications. AIM:To compare the use of gastroprotective strategies in NSAID users in three countries, and the subsequent impact of rofecoxib withdrawal. METHODS:We con...

journal_title：Alimentary pharmacology & therapeutics

authors： Valkhoff VE,van Soest EM,Masclee GM,de Bie S,Mazzaglia G,Molokhia M,Kuipers EJ,Sturkenboom MC

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Pancreatic exocrine insufficiency (PEI) results in maldigestion, leading to abdominal pain, steatorrhoea, malnutrition and weight loss. AIM:To assess the efficacy and safety of pancreatin (Creon 40000 MMS) in treating PEI due to chronic pancreatitis (CP). METHODS:This was a 1-week, double-blind, randomised...

journal_title：Alimentary pharmacology & therapeutics

authors： Thorat V,Reddy N,Bhatia S,Bapaye A,Rajkumar JS,Kini DD,Kalla MM,Ramesh H

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Idiopathic mesenteric phlebosclerosis (IMP) is a rare disease, characterised by thickening of the wall of the right hemicolon with calcification of mesenteric veins. However, the aetiology remains unknown. AIM:To investigate the possible association of herbal medicines with IMP. METHOD:The clinical data of...

journal_title：Alimentary pharmacology & therapeutics

authors： Hiramatsu K,Sakata H,Horita Y,Orita N,Kida A,Mizukami A,Miyazawa M,Hirai S,Shimatani A,Matsuda K,Matsuda M,Ogino H,Fujinaga H,Terada I,Shimizu K,Uchiyama A,Ishizawa S,Abo H,Demachi H,Noda Y

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Low bone mineral density (BMD) has been reported in both paediatric and adult patients with non-alcoholic fatty liver disease (NAFLD). The mechanisms behind the reduced BMD in NAFLD are still not completely understood. AIM:To provide a critical overview of the pathophysiological pathways linking NAFLD, redu...

journal_title：Alimentary pharmacology & therapeutics

authors： Yilmaz Y

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Strong acid inhibition using esomeprazole increases cure rates with triple therapy and 10-day treatments are more effective than 7-day ones. The combination of amoxicillin plus metronidazole at full doses, and using a physiologically-correct schedule three times a day, and has been shown to overcome metronid...

journal_title：Alimentary pharmacology & therapeutics

authors： Sánchez-Delgado J,García-Iglesias P,Castro-Fernández M,Bory F,Barenys M,Bujanda L,Lisozain J,Calvo MM,Torra S,Gisbert JP,Calvet X

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:Despite similar clinical symptoms, collagenous colitis (CC) and lymphocytic colitis (LC) are considered two distinct disease entities. AIM:To compare pathoanatomical findings, clinical presentations, risk factors, course of diseases and response to treatment in CC and LC to establish whether they could be s...

journal_title：Alimentary pharmacology & therapeutics

authors： Rasmussen MA,Munck LK

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:It is believed that women with inflammatory bowel disease (IBD) have heightened symptoms around their menses. However, there is little information regarding normative changes and which symptoms emerge in relation to menses. AIM:To determine the relationship between gastrointestinal and other symptoms and me...

journal_title：Alimentary pharmacology & therapeutics

authors： Bernstein MT,Graff LA,Targownik LE,Downing K,Shafer LA,Rawsthorne P,Bernstein CN,Avery L

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:The sequential organ failure assessment (SOFA) score is an effective triage marker following single time point paracetamol (acetaminophen) overdose, but has not been evaluated following staggered (multiple supratherapeutic doses over >8 h, resulting in cumulative dose of >4 g/day) overdoses. AIM:To evaluate...

journal_title：Alimentary pharmacology & therapeutics

authors： Craig DG,Zafar S,Reid TW,Martin KG,Davidson JS,Hayes PC,Simpson KJ

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Vasoactive medications such as vasopressin, somatostatin and their analogues (terlipressin, vapreotide and octreotide) are commonly used for the treatment of acute variceal bleeding. However, the risks and benefits of these interventions are not well understood. AIM:To undertake a meta-analysis of the effic...

journal_title：Alimentary pharmacology & therapeutics

authors： Wells M,Chande N,Adams P,Beaton M,Levstik M,Boyce E,Mrkobrada M

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Helicobacter-negative gastritis and duodenitis occur more often in patients with inflammatory bowel disease (IBD) than in non-IBD controls. Preliminary evidence suggests that they are particularly common among children. AIM:To study the age-specific occurrence of gastritis and duodenitis among paediatric IB...

journal_title：Alimentary pharmacology & therapeutics

authors： Genta RM,Sonnenberg A

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Both simple proportions and statistical tests are utilised for symptom-reflux association. We systematically compared three such tests in a clinical setting. AIM:To compare the three commonly used symptom reflux association tests in a large cohort of patients undergoing ambulatory pH monitoring for the eval...

journal_title：Alimentary pharmacology & therapeutics

authors： Kushnir VM,Sathyamurthy A,Drapekin J,Gaddam S,Sayuk GS,Gyawali CP

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Third-generation cephalosporins (TGC) constitute the empirical first-line therapy for spontaneous bacterial peritonitis (SBP). Hospitalisation, invasive procedures and use of antibiotics may challenge this concept due to an increase in enterococci and other TGC-resistant microorganisms. AIM:To determine pre...

journal_title：Alimentary pharmacology & therapeutics

authors： Reuken PA,Pletz MW,Baier M,Pfister W,Stallmach A,Bruns T

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Liver transplantation (LT) offers a possible cure for carefully selected patients with hepatocellular carcinoma (HCC). Studies report that preoperative alpha-fetoprotein (AFP) is a prognostic indicator that can predict survival and recurrence in these patients. AIM:To undertake a systematic review of availa...

journal_title：Alimentary pharmacology & therapeutics

authors： Hakeem AR,Young RS,Marangoni G,Lodge JP,Prasad KR

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Malnutrition and jaundice are independent prognostic factors in cirrhosis. AIM:To assess the impact of enteral nutrition on the survival of alcoholic cirrhotic patients with jaundice but without acute alcoholic hepatitis. METHODS:The study was a multicentre prospective randomised controlled trial comparing...

journal_title：Alimentary pharmacology & therapeutics

authors： Dupont B,Dao T,Joubert C,Dupont-Lucas C,Gloro R,Nguyen-Khac E,Beaujard E,Mathurin P,Vastel E,Musikas M,Ollivier I,Piquet MA

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Peptic ulcer bleeding remains a major healthcare problem despite decreasing prevalence of peptic ulcer disease. The role of chronic obstructive pulmonary disease (COPD) in the risk of peptic ulcer bleeding has not yet been established. AIM:To determine if COPD patients have a higher risk of peptic ulcer ble...

journal_title：Alimentary pharmacology & therapeutics

authors： Huang KW,Luo JC,Leu HB,Lin HC,Lee FY,Chan WL,Lin SJ,Chen JW,Chang FY

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:In some cases, Helicobacter pylori infection persists even after three eradication treatments. AIM:To evaluate the efficacy of an empirical fourth-line rescue regimen with rifabutin in patients with three eradication failures. METHODS: DESIGN:Multicentre, prospective study. PATIENTS:In whom the following...

journal_title：Alimentary pharmacology & therapeutics

authors： Gisbert JP,Castro-Fernandez M,Perez-Aisa A,Cosme A,Molina-Infante J,Rodrigo L,Modolell I,Cabriada JL,Gisbert JL,Lamas E,Marcos E,Calvet X

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:The nonselective 5-HT(4) receptor agonists, cisapride and tegaserod have been associated with cardiovascular adverse events (AEs). AIM:To perform a systematic review of the safety profile, particularly cardiovascular, of 5-HT(4) agonists developed for gastrointestinal disorders, and a nonsystematic summary ...

journal_title：Alimentary pharmacology & therapeutics

authors： Tack J,Camilleri M,Chang L,Chey WD,Galligan JJ,Lacy BE,Müller-Lissner S,Quigley EM,Schuurkes J,De Maeyer JH,Stanghellini V

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:The increasing incidence of Clostridium difficile (C. difficile) infection (CDI) among patients with inflammatory bowel disease is well recognised. However, most studies have focused on demonstrating that CDI is associated with adverse outcomes in IBD patients. Few have attempted to identify predictors of se...

journal_title：Alimentary pharmacology & therapeutics

authors： Ananthakrishnan AN,Guzman-Perez R,Gainer V,Cai T,Churchill S,Kohane I,Plenge RM,Murphy S

更新日期：2012-04-01 00:00:00